摘要目的:比较不同方式泵注美罗培南治疗重症监护病房(ICU)重症感染的效果。方法:抽取2019年10月至2021年11月平煤神马医疗集团总医院ICU重症感染患者84例，按照给药方式分为观察组与对照组，每组42例。对照组予以单剂量间歇给药，泵注美罗培南用药时间<30 min，观察组泵注美罗培南用药时间延长至3 h。比较两组治疗效果、序贯器官衰竭评估(SOFA)评分、恢复情况、病情严重程度、不良反应发生率、炎性因子水平[C反应蛋白(CRP)、降钙素原(PCT)]。结果:观察组总有效率(95.24%，40/42)高于对照组(80.95%，34/42)，差异有统计学意义( P<0.05)。治疗后，观察组SOFA评分及CRP、PCT水平低于对照组( P均<0.05)。观察组呼吸机通气时间、ICU治疗时间及住院时间短于对照组( P<0.05)。治疗后，观察组病情严重程度分值低于对照组( P<0.05)。观察组不良反应发生率(19.05%，8/42)与对照组(26.19%，11/42)比较，差异未见统计学意义( P>0.05)。 结论:泵注美罗培南延长给药时间治疗ICU重症感染能提高治疗效果，缓解炎症状态，及时改善病情。

abstractsObjective:To compare the effects of different ways of pump injection of meropenem on severe infection in intensive care unit (ICU).Method:A total of 84 patients with severe infection in the ICU of General Hospital of Pingmei Shenma Medical Group from October 2019 to November 2021 were selected, and they were divided into observation group and control group according to the mode of administration, with 42 cases in each group. The control group was given a single dose of intermittent administration, and the time of infusion of meropenem was less than 30 min. While the treatment time of meropenem by pump in the observation group was extended to 3 h. The treatment effect, inflammatory factor levels including C-reactive protein (CRP) and procalcitonin (PCT), sequential organ failure assessment (SOFA) score, recovery condition, disease severity, incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group (95.24%, 40/42) was higher than that of the control group (80.95%, 34/42), and the difference was significant ( P<0.05). After treatment, the SOFA score, CRP level and PCT level of the observation group were lower than those of the control group (all P<0.05). The ventilator ventilation time, ICU treatment time and hospital stay of the observation group were shorter than those of the control group ( P<0.05). After treatment, the disease severity score of the observation group was lower than that of the control group ( P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (19.05%, 8/42) and the control group (26.19%, 11/42), P>0.05. Conclusions:Pump injection of meropenem for prolonged administration time in the treatment of severe infection in ICU can improve the therapeutic effect, relieve the inflammatory state and improve the disease condition in time.