摘要目的:探讨七氟烷吸入麻醉复合丙泊酚静脉麻醉应用于小儿斜视矫正手术的效果。方法:队列研究。抽取2020年2月至2023年5月于陕西省第二人民医院接受手术治疗的80例斜视患儿为研究对象，按照信封法随机分为对照组与研究组，每组40例。对照组单用七氟烷吸入麻醉，研究组予以七氟烷吸入复合丙泊酚静脉麻醉。记录并比较两组不同时间生命体征[平均动脉压(MAP)、心率]，比较两组麻醉恢复情况(恢复自主呼吸、拔除喉罩、苏醒所需时间)及麻醉相关不良反应发生情况。结果:诱导前及拔管后，两组MAP、心率水平比较差异未见统计学意义( P>0.05)；插管即刻，两组MAP比较差异有统计学意义( P<0.05)。研究组恢复自主呼吸、苏醒所需时间均少于对照组( P均<0.05)，两组拔除喉罩时间比较差异未见统计学意义( P>0.05)。研究组胃肠道反应、苏醒期躁动、唤醒时疼痛、呼吸抑制发生率均低于对照组( P均<0.05)。 结论:七氟烷吸入复合丙泊酚静脉麻醉应用于斜视患儿手术中有利于确保机体生命体征平稳，促进患儿麻醉后尽快恢复，降低麻醉相关不良反应发生风险。

abstractsObjective:To investigate the effect of sevoflurane inhalation anesthesia combined with propofol intravenous anesthesia in corrective surgery for strabismus in children.Methods:A total of 80 children with strabismus who underwent surgery in Shaanxi Second People’s Hospital from February 2020 to May 2023 were selected as research objects for a cohort study. And they were randomly divided into a control group and a study group by envelope method, with 40 cases in each group. The control group received sevoflurane inhalation anesthesia alone, while the study group received sevoflurane inhalation combined with propofol intravenous anesthesia. The vital signs including mean arterial pressure (MAP) and heart rate at different time points were compared between the two groups. The anesthesia recovery condition (time required for recovery of autonomous breathing, removing laryngeal mask and wakening) and incidence of adverse reactions related to anesthesia were compared between the two groups.Results:There was no significant difference in levels of MAP and heart rate between the two groups before anesthesia induction and after extubation ( P>0.05). There was a significant difference in the MAP immediately after intubation between the two groups ( P<0.05). The time required for recovery of autonomous breathing and wakening of the study group was lower than that of the control group (all P<0.05). There was no significant difference in time required for removing laryngeal mask between the two groups ( P>0.05). The incidence of gastrointestinal reactions, agitation during recovery, pain during awakening, and respiratory depression in the study group were lower than those in the control group (all P<0.05). Conclusions:The use of sevoflurane inhalation combined with propofol intravenous anesthesia in children undergoing strabismus surgery is conductive to ensuring stable vital signs, promoting rapid recovery after anesthesia, and reducing the risk of anesthesia related adverse reactions.