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Research progress in natural N-glycosides and synthetic methodologies for the formation of N-glycosidic bonds

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学术成果认领

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摘要N-glycosides comprise a broad range of compounds,some of which have demonstrated a variety of bioactivities,such as antiviral,an-titumor,and antibacterial activities.Serving as essential building blocks for DNA and RNA,nucleosides are a particularly important sub-class of N-glycosides.Accordingly,natural N-glycosides and their analogs have garnered great interests of both organic and pharma-ceutical chemists,who have developed numerous synthetic methods for the preparation of N-glycosides.By reviewing the natural N-glycosides published between 1980 and 2023,this article summarizes current strategies for synthesizing N-glycosides,aiming to provide support for the development and research of N-glycosides.

作者 Yingting Xia ^[1] Qingxia Xu ^[2] Alastair N.Herron ^[3] Wenjun Wang ^[1] Lidong Shao ^[4] Guodong Li ^[4] An Liu ^[2] Jintang Cheng ^[2] 学术成果认领

作者单位 State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China;School of Chinese Medicine,Yunnan University of Traditional Chinese Medicine,Kunming,China ^[1] State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China ^[2] Gilead Sciences,Inc,Foster City,CA,USA ^[3] School of Chinese Medicine,Yunnan University of Traditional Chinese Medicine,Kunming,China ^[4]

关键词 N-glycosides Natural products Bioactivities Synthetic methodology Regioselectivity

栏目名称

Review

DOI 10.1097/st9.0000000000000035

发布时间 2025-06-17（万方平台首次上网日期，不代表论文的发表时间）