摘要Purpose: To investigate the intervention effects of using traditional Chinese Guqin music and Chinese Calligraphy handwriting (CCH) for patients with Primary Insomnia. Methods: A total of ninety patients were assigned to control group, Guqin group, and calligraphy group for 8 weeks. For 5 days a week, patients' heart rate variability (HRV) and frontal midline (FZ) electroencephalographic signals were recorded in a clinic during interventional period while either listening to Guqin music or writing calligraphy. Patients in the control group remained in rest condition. Results: For the Guqin group, the higher low?frequency?range HRV of coherence was found with marginal significance (P = 0.055), and heart rate was significantly reduced (P < 0.05) during the 4th week in listening to Guqin music compared to the prerest period. For listening to Guqin music or calligraphy intervention, FZ δ, FZ θ, and FZ α waves in the 8th week compared to the 0th week (Pre Intervention) showed a significantly enhanced effect (P < 0.05). Between the three groups, for heart rate and FZ δ and FZ θ waves, calligraphy group showed significantly increased heart rate than the Guqin group (P < 0.001)and the control group (P = 0.004); increased FZ δ wave than the Guqin group (P < 0.001) and the control group (P < 0.001); and increased FZ θ wave than the Guqin group (P = 0.024) and the control group (P = 0.008) respectively. Conclusion: Positive intervention effects on HRV coherence of Guqin music; FZ δ, FZ θ, and FZ α waves of Guqin music and calligraphy proved that Guqin music together with calligraphy training helping to promote physical and mental health, thereby it contributes to the clinical application of TCM Psychology for patients with insomnia syndrome.