换一批Efficacy of green tea extract on PC3 prostate cancer cells through upregulation of miR-195 expression and suppression of epithelial to mesenchymal transition
摘要OBJECTIVE:To evaluate anticancer efficacy of green tea extract(GTE)on PC3 prostate cancer cells.METHODS:By using quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot methods,the expression of miR-195 and the epithelial to mesenchymal transition(EMT)markers such as E-cadherin and vimentin was analyzed.RESULTS:Based on the results of 2D and 3D cell culture models,the inhibition of EMT and up regulation of miR-195 expression were detected.CONCLUSIONS:Our findings will be helpful to design anti-tumor regimens with natural product original,and more studies will be required to identify the related mechanisms involving anticancer activities of green tea via miRNAs.
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DOI
10.19852/j.cnki.jtcm.2022.05.002
发布时间
2023-05-19（万方平台首次上网日期，不代表论文的发表时间）
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