摘要OBJECTIVE:To explore the value and factors influencing the maintenance of valid Traditional Chinese Medicine compound prescription patents for the management of mammary gland hyperplasia.METHODS:The State Intellectual Property Office Patents Database,China Patent Information Center Patents Database,Soopat Patent Search Platform,and CNIPR Search Platform of Chinese and Foreign Patent Database were searched to identify Traditional Chinese Medicine compound prescription patents for mammary gland hyperplasia that had been maintained for at least 5 years.Logistic regression analysis was used to detect the factors influencing the maintenance of valid patents.RESULTS:From 1 January 1993 to 31 December 2019,a total of 1228,Traditional Chinese Medicine compound prescription patents for mammary gland hyperplasia were authorized.Of these applications,381 patents were granted and only 176 patents were maintained for more than 5 years.The five independent variables assessed in this study all had significant explanatory functions.CONCLUSIONS:The maintenance of valid patents for Traditional Chinese Medicine compound prescriptions for treating mammary gland hyperplasia is of great importance.The maintenance of such patents depends on many factors,such as the concentration of effective herbs,number of dependent claims,provision of new dosage forms and detailed experimental data,and transfer of patent rights.