摘要OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency type.METHODS:Forty-five female Sprague-Dawley rats were randomly divided for two times.The first time,they were randomly divided into model group and blank group(Group C)according to 2:1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1:1.15 in each group.For Group A and Group B,the lung deficiency model was made by"sulfur-moxa fumigation",and then the allergic rhinitis model was established by"ovalbumin(OVA)sensitization".Then catgut embedding was performed at acupoints in Group A and not in Group B.After 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and TLR-2.RESULTS:IgE level(μg/mL)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P＜0.001).IL-4 level(pg/mL)was(14.2 ±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P＜0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810± 0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P＜0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still continued.To achieve further treatment,prolonging the catgut embedding time is necessary.