Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction:a literature review
摘要Tanshinone Ⅱ A(Tan Ⅱ A)is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen(Radix Salviae Miltiorrhizae)that has various pharmacological properties,including anti-inflammatory,antibacterial,and antioxidative effects.Sepsis is a life-threatening organ dysfunction induced by a dysregulated host response to infection.Recently,increasing attention has been paid to sepsis-induced dysfunction of the intestine,car-diovascular system,lungs,kidneys,liver,and other organs.Experimental studies have shown that Tan ⅡA has therapeutic potential for sepsis-induced organ dysfunction owing to its anti-inflammatory,anti-apoptotic and regulatory effects on multiple signalling pathways.The purpose of this article is to evaluate the potential multiorgan protective effects of Tan ⅡA in sepsis.
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