摘要OBJECTIVE:To evaluate the efficacy of Tongyang Fumai decoction(通阳复脉方,TYFM)on the quality of life(QOL)as a complementary therapy for sick sinus syndrome(SSS).METHODS:This randomized controlled study involved 224 patients with symptomatic SSS.Patients were randomly assigned to either the TYFM group or the control group(receiving theophylline sustained-release tablets).The primary endpoints included changes in average heart rate,the longest R to R(RR)interval,and the occurrences of long RR intervals.Secondary endpoints comprised the Short Form(SF)-36 questionnaires,the Self-Rating Anxiety Scale(SAS),and the Self-Rating Depression Scale(SDS).RESULTS:TYFM significantly improved average heart rate(TYFM:6 bpm vs control:3 bpm,P＜0.01),shortened longest RR interval(TYFM:-0.20 s vs control:-0.0027 s,P＜0.05),and reduced numbers of long RR(TYFM:-99 vs control:-59,P＜0.01).In SF-36,TYFM enhanced physical and mental components(P＜0.01),outperforming the control group.TYFM also improved eight SF-36 dimensions significantly(P＜0.05 or P＜0.01).Regarding SAS and SDS,TYFM reduced scores significantly(P＜0.01),while SAS improved in the control group(P＜0.01),with no change in SDS.Statistically significant differences(P＜0.01)were observed in SAS and SDS between TYFM and control groups post-intervention.CONCLUSIONS:TYFM emerges as a promising alternative strategy for treating SSS,demonstrating favorable therapeutic effects and significant improvements in the quality of life for patients with SSS.