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摘要Autophagy, a lysosomai degradative pathway to clear up aggregated proteins aged anddamaged organelles.Hidden effect of delimitation Induced autophagy via nano-materials remain unknown its material/protein interaction and robust cellular signalingfeature.Here we performed the surface characteristic elimination of Mn3O4 nanomaterials, i.e.dissociations of Ligand (Ethonal Amine) from Mn3O4 surface by thermaleffect which denotes as Mn3O4 (A) shows distinguished effect with Mn3O4 to cleaveuniformly desired protein (Beclin1) or ATG6 to accelerate cellular mechanism onemphasisof Autophagy formation & it's switch to Apoptosis.Here we are trying to<br>　　simplify material characteristics via surface ligand (Ethanol Amine) dissociation todisturb cellular effect via Beclin1 cleavage to tune LC3-Ⅱ conversion.Beclin1 plays acrucial role to initiate Autophagy & have comprehensive site of cleavage whichregulates crucial components of the autophagy-inducing complex.Here also our studyshows distinguished effect of Mn3O4 nanomaterials surface ligand dissociation uniqueproperty can able to cleave desired protein (Beclin1) to tune cellular mechanism onemphasis of Autophagy acceleration & switch to apoptosis.Our model will also help tosimplify the conflict of Apoptosis-Autophagy on base of its unique chemical compoundnano-property with its derived surface physical changes.Here we magnifies Mn3O4physical surfaces changes in context of Beclin1 distinguished cleavage which directlyand, or indirectly accelerate or regulate autophagosomes formation and switch toApoptosis.Apoptotic cell death mediates by PI3KC3 cleavage & Caspase activation.