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摘要PARTICLE CASSETTE FOR A NEEDLE NEEDLE SYRINGE DEVICE AS WELL AS METHOD, APPARATUS AND PARTS KIT FOR USE IN THE SAME PRODUCTION, AND FIRST AND SECOND PARTS THEREOF. The present invention relates to a method of producing a particle cassette for a needleless syringe device which alleviates the problems of providing a hermetically sealed particle confinement chamber from the environment. A predetermined force is applied in the longitudinal direction to press the first and second cassette parts together to cause plastic deformation of a portion of the first cassette part to create said hermetically sealed chamber. The cassette parts are preferably made of PETG and have rupturable membranes attached thereto, preferably made of PET. The sealing is preferably obtained at the end of a protrusion on the first tapered cassette part which interacts with the membrane of the second cassette part.