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摘要²²²The present invention relates to methods of inhibiting infection by RNA ²viruses with complexes of an activator of RNase L and an oligonucleotide that ²is capable of binding to the genome, antigenome or mRNAs of a negative strand ²RNA virus to specifically cleave the genomic or antigenomic RNA strand of the ²virus. In accordance with the present invention, the methods and complexes of ²the invention may be applied to target any negative strand RNA virus. The ²invention in one emboidment relates to a covalently linked complex of an ²oligonucleotide that is capable of binding to the genomic or antigenomic ²template RNA strand of a negative strand RNA virus and/or binding to an mRNA ²of a viral protein (an "antisense oligonucleotide") coupled to an activator of ²RNase L. In a preferred embodiment of the present invention, the ²oligonucleotide component of the complex is complementary to a region of the ²viral genomic RNA strand characterized by repeated or consensus sequences.²