换一批TREATMENT OF PATIENTS DIAGNOSED WITH PANCREATIC DUCTAL ADENOCARCINOMA USING USING MONOCLONAL ANTIBODIES AGAINST THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)
摘要The present invention relates to the field of immunotherapy of cancer, in particular pancreatic ductal adenocarcinoma (PDAC). More specifically, the present invention provides means and methods for treatment of a population of PDAC patients suffering from PDAC tumors which express wild-type KRAS, HRAS or NRAS. The means and methods of the invention envisaged administration of an anti-EGFR antibody or antigen-binding fragment or peptide thereof to the patients. Means and methods for selecting patients and tumors for their responsiveness to the treatment are also provided herein.
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申请/专利号
EP16753597A
申请日期
2016-07-27
公开/公告号
公开/公告日
2021-04-07
主分类号
A61K39/395（含有抗原或抗体的医药配制品）
分类号
A61K39/395 C07K16/32 A61K31/7068 C12Q1/6886 C12Q2600/106 G01N2800/52 A61K39/39558 A61P35/00 A61K31/337 A61K31/517 A61K33/24 A61K45/06 A61K33/243 G01N33/57575 C07K16/22 C07K16/32 C12Q1/6886 C07K2317/70 C07K2317/734 C07K2317/76 C07K2317/73 C07K2317/732 C12Q2600/106 C12Q2600/158 A61K2039/505 A61K39/395 A61P35/00 A61K33/243 C07K16/32 A61K31/7068 C12Q1/6886 G01N2800/52 A61K39/395 C12Q2600/106 A61K33/243 G01N33/57575 A61K39/39558 A61P35/00 A61K31/337 A61K31/517 A61K45/06 A61K2039/505 A61K2300/00
申请/专利权人
InnoCIMAb Pte Ltd Oncoscience AG
发明/设计人
学术成果认领
专利代理机构
Schiweck Weinzierl Koch
Patentanwälte Partnerschaft mbB
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