换一批摘要This invention provides peptide compounds that bind to either a fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR activity. Preferably, the FGFR is FGFR2-IIIC. Preferably, the FGF is basic FGF. Preferably the peptide compound comprises an amino acid sequence: (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y-(M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO: 1). The invention further comprises pharmaceutical compositions comprising the peptide compounds of the invention and a pharmaceutically acceptable carrier. The invention still further provides methods of modulating FGFR activity using the peptide compounds of the invention.
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申请/专利号
EP97950623A
申请日期
1997-11-12
公开/公告号
公开/公告日
1999-09-15
主分类号
A61K38/00（含肽的医药配制品）
分类号
A61K38/00 C07K7/06 C07K14/50 A61P1/18 A61P13/08 A61P15/08 A61P17/02 A61P17/06 A61P19/02 A61P29/00 A61P35/00 A61P35/02 A61P43/00 A61P9/00 A61P3/10 C07K7/06 C07K14/50 A61K38/00
发明/设计人
学术成果认领
专利代理机构
Price, Vincent Andrew, et al
国别省市代码
美国;US
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