换一批TARGET SEQUENCES AND METHODS TO IDENTIFY THE SAME, USEFUL IN TREATMENT OF NEURODEGENERATIVE DISEASES
摘要The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and / or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and / or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS.
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申请/专利号
EP2009051184W
申请日期
2009-02-03
公开/公告号
公开/公告日
2009-08-13
主分类号
A61P25/00（治疗神经系统疾病的药物）
分类号
A61P25/00 A61P25/14 A61P25/16 A61P25/28 A61P43/00 G01N33/5023 G01N2500/04 G01N2800/2835 G01N33/5023 G01N2500/04 G01N2800/2835
申请/专利权人
GALAPAGOS NV FISCHER, David Frederik JANSSEN, Richard Antonius Jozef DE PRIL, Remko VAN STEENHOVEN, Desire Maria Petronella Catharina KWAK, Seung HOWLAND, David S. SIGNER, Ethan
发明/设计人
学术成果认领
代理人
NICHOL, Maria
国别省市代码
比利时;BE
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