换一批MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
摘要The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETs.
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申请/专利号
EP2010061272W
申请日期
2010-08-03
公开/公告号
公开/公告日
2011-02-10
主分类号
A61K31/7088（含有机有效成分的医药配制品）
分类号
A61K31/7088 A61P25/28 G01N33/6896 G01N2500/04 G01N2500/10 G01N2800/2835
申请/专利权人
GALAPAGOS NV FISCHER, David, Frederik DE PRIL, Remko VAN STEENHOVEN, Desiré, Maria, Petronella, Catharina JANSSEN, Richard, Antonius, Jozef KWAK, Seung HOWLAND, David SIGNER, Ethan
发明/设计人
学术成果认领
代理人
TEUTEN, Andrew et al.
国别省市代码
比利时;BE
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