换一批RNASE L ACTIVATORS AND ANTISENSE OLIGONUCLEOTIDES EFFECTIVE TO TREAT TELOMERASE- EXPRESSING MALIGNANCIES
摘要The present invention relates to chimeric molecules comprising an oligonucleotide complementary to a region of the ribonucleotide component of telomerase attached to an activator of RNase L (activator-antisense complex) which specifically cleaves the ribonucleotide portion of a telomerase enzyme. The present invention relates to methods of inhibiting telomerase enzymatic activity with activator-antisense complexes targeted to the RNA component of telomerase. The present invention further relates to methods of treating malignant neoplastic disease, wherein the malignant cells contain a telomerase activity that is necessary for the growth of the malignant cells.
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申请/专利号
US1812598A
申请日期
1998-02-03
公开/公告号
公开/公告日
2001-07-12
主分类号
A61K38/00（含肽的医药配制品）
分类号
A61K38/00 A61P35/00 A61P43/00 C12N15/1137 C12N2310/317 C12N2310/3183 A61K38/00 C12N15/1137 C12N2310/317 C12N2310/3183
发明/设计人
学术成果认领
主权项
29
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