换一批摘要Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEAin vivo.
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申请/专利号
US2005007831W
申请日期
2005-03-11
公开/公告号
公开/公告日
2006-09-14
主分类号
A61K2039/505（医用、牙科用或梳妆用的配制品）
分类号
A61K2039/505 C07K16/3007 C07K16/32 C07K16/465 C07K2317/24 C07K2317/56 C07K2317/565 C07K2317/567 C07K2317/626 C07K2317/92 C12N15/1089 A61P35/00 G01N33/575 C07K16/3007 C07K2317/626 C07K2317/567 C07K16/32 C07K2317/92 C07K16/465 A61K2039/505 C07K2317/24 C07K2317/56 C07K2317/565 C12N15/1089 G01N33/575
申请/专利权人
CITY OF HOPE YAZAKI, PAUL, J. SHERMAN, MARK, A. SHIVELY, JOHN, E.. RAUBITSCHEK, ANDREW, A. WU, ANNA, M.
发明/设计人
学术成果认领
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