换一批METHODS FOR REGULATING A CELL-MEDIATED IMMUNE RESPONSE BY BLOCKING LYMPHOCYTIC SIGNALS AND BY BLOCKING LFA-1 MEDIATED ADHESION
摘要The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.
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申请/专利号
US0118619W
申请日期
2001-06-08
公开/公告号
公开/公告日
2001-12-20
主分类号
A61K2039/505（医用、牙科用或梳妆用的配制品）
分类号
A61K2039/505 C07K16/2845 C07K16/2875 C07K2319/00 C07K2319/30 A61K38/1709 A61K38/1774 A61K38/1777 A61K45/06 A61P1/04 A61P1/16 A61P17/00 A61P17/02 A61P17/06 A61P21/00 A61P21/04 A61P25/00 A61P27/02 A61P29/00 A61P3/00 A61P35/00 A61P35/02 A61P37/00 A61P37/02 A61P37/06 A61P5/40 A61P7/04 A61P7/06 A61P3/10 A61K39/395 C07K16/2845 A61K2039/505 C07K16/2875 C07K2319/30 C07K2319/00 A61K38/1777 A61K38/1709 A61K38/1774 A61K45/06
申请/专利权人
BRISTOL-MYERS SQUIBB COMPANY TOWNSEND, Robert, M. TODDERUD, Charles, Gordon PEACH, Robert, J.
发明/设计人
学术成果认领
代理人
SHER, Audrey, F.
国别省市代码
美国;US
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