首页> Journal of medicinal chemistry> Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.

Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.

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第一作者： Jennifer X,Qiao

第一单位： Research and Development, Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States.

作者： Jennifer X,Qiao ^[1] ; Tammy C,Wang ; Réjean,Ruel ; Carl,Thibeault ; Alexandre,L'Heureux ; William A,Schumacher ; Steven A,Spronk ; Sheldon,Hiebert ; Gilles,Bouthillier ; John,Lloyd ; Zulan,Pi ; Dora M,Schnur ; Lynn M,Abell ; Ji,Hua ; Laura A,Price ; Eddie,Liu ; Qimin,Wu ; Thomas E,Steinbacher ; Jeffrey S,Bostwick ; Ming,Chang ; Joanna,Zheng ; Qi,Gao ; Baoqing,Ma ; Patricia A,McDonnell ; Christine S,Huang ; Robert,Rehfuss ; Ruth R,Wexler ; Patrick Y S,Lam

作者单位： Research and Development, Bristol-Myers Squibb Company , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States. ^[1]