摘要1例56岁男性患者,因鼻咽癌行放疗+西妥昔单抗分子靶向治疗.首次静脉滴注西妥昔单抗600 mg,此后400 mg/次,1次/周.首次用药后第11天患者面部及胸背部出现红色斑丘疹,并伴有脓疱,同时口腔黏膜红肿.给予氯雷他定抗过敏,呋喃西林溶液漱口.第4次用药开始将西妥昔单抗剂量减为300 mg,症状未见好转,患者出现口腔溃疡,舌体呈“地图”样改变,伴颈部皮肤糜烂.加用碳酸氢钠溶液漱口并给予抗感染等治疗.共用药6次后停用西妥昔单抗.停药后约6周患者皮肤、口腔黏膜损伤好转.

abstractsA 56-year-old man received a radiotherapy plus cetuximab molecular targeted therapy for nasopharyngeal carcinoma.He received an Ⅳ infusion of cetuximab 600 mg first time,and then 400 mg once a week.Eleven days after the first medication,red macules and pustules appeared on his face,chest and back.His oral mucosa was red and swollen at the same time.Loratadine and furancilin solution were given for anti-allergic treatment and gargle.The dose of cetuximab decreased to 300 mg on the 4th medication,but the symptoms were not improved.He developed ulcers in mouth,map-like changes in corpora linguae,and skin erosion in neck.A gargle with sodium hydrocarbonate solution and anti-infective therapy were given.Cetuximab was withdrawn after 6 times of medication.About 6 weeks after drug withdrawl,the patient's injuries in his skin and oral mucosal were improved.