摘要旋毛虫、蛔虫和带绦虫均是可寄生于人体的蠕虫,当入侵宿主后可诱导机体产生一定的免疫应答,包括免疫细胞的活化及细胞因子的产生等,这些免疫应答与抗肿瘤免疫应答有相似之处.近年来,有动物实验研究发现,机体感染旋毛虫、蛔虫或带绦虫后,可在一定程度上抑制多种肿瘤的发展.作者就上述几种蠕虫抗肝癌、肺癌、乳腺癌、恶性黑色素瘤、骨髓瘤及其他肿瘤的作用进行综述,以期为蠕虫感染免疫应用于肿瘤的治疗提供有价值的参考.

abstractsTrichinella spiralis,Ascaris lumbricoides,and Taenia crassiceps are all parasitic helminths that can infect humans.After invading host,the parasites can induce immune responses such as activation of immune cells and induction of cytokines in the host.The immune responses induced by parasitic helminths have similarities with anti-tumor immune responses.Recent studies have demonstrated that infection of Trichinella spiralis,Ascaris lumbricoides,or Taenia crassiceps can inhibit the development of several kinds of tumors to some extent.In this paper,the progress of anti-tumor effects induced by the above-mentioned helminths on liver cancer,lung cancer,breast cancer,malignant melanoma,myeloma,and other cancers is reviewed,which may provide a valuable reference for treatment of tumors by the immune response to helminthic infection.