摘要目的 观察肠内营养乳剂对胃肠道肿瘤患者营养状况和免疫功能的影响.方法 选取运城市中心医院胃肠外科2014年1月至2017年1月治疗的胃肠道肿瘤患者100例为研究对象,采用随机数字表法分为两组,每组50例.两组患者均行化疗,观察组在化疗期间给予肠内营养乳剂,比较两组患者的营养状况指标、免疫功能指标、化疗效果、不良反应发生率.结果 治疗后,观察组前清蛋白、清蛋白、转铁蛋白、血红蛋白分别为(0.30 ± 0.07)g/L、(32.93 ± 1.67)g/L、(2.61 ± 0.15)g/L、(109.94 ± 2.31)g/L,对照组分别为(0.19 ± 0.09)g/L、(30.89 ± 1.49)g/L、(2.49 ± 0.14)g/L、(108.07 ± 2.04) g/L,两组均差异有统计学意义(t=6.822、6.445、4.135、4.291,均P<0.05);治疗后,观察组CD+3 、CD4/CD8、NK细胞分别为(43.84 ± 7.65)% 、(1.70 ± 0.18)、(37.78 ± 6.51)% ,对照组分别为(36.12 ± 6.57)% 、(1.52 ± 0.19)、(31.07 ± 4.20)% ,两组均差异有统计学意义(t=5.413、4.863、6.124,均P<0.05);观察组客观缓解率(64% )明显高于对照组(44% ) ( χ2 =4.026,P<0.05),其不良反应发生率(18% )显著低于对照组的36% (χ2 =4.110,P<0.05).结论 肠内营养乳剂可有效改善胃肠道肿瘤患者化疗期间的营养状况、免疫功能,还能有效增强化疗敏感性,提高化疗效果,安全性也较可靠.

abstractsObjective To observe the effect of enteral nutritional emulsion on nutritional status and immune function in patients with gastrointestinal cancer.Methods From January 2014 to January 2017,100 patients with gastrointestinal cancer in Yuncheng Central Hospital were selected in the research and randomly divided into two groups according to the digital table, with 50 cases in each group. All the patients underwent chemotherapy, the observation group was given enteral nutritional emulsion during chemotherapy. The indicators of nutritional status, immune function, the effect of chemotherapy, the incidence of adverse reactions were compared between the two groups.Results After treatment,the prealbumin,albumin,transferrin and hemoglobin levels in the observation group were (0.30 ± 0.07)g/L,(32.93 ± 1.67)g/L,(2.61 ± 0.15) g/L,(109.94 ± 2.31)g/L,respectively,which in the control group were (0.19 ± 0.09)g/L,(30.89 ± 1.49)g/L,(2.49 ± 0.14)g/L,(108.07 ± 2.04)g/L,respectively, there were statistically significant differences between the two groups(t=6.822,6.445,4.135,4.291,all P<0.05). After treatment,the CD+3 ,CD4/CD8,NK cells in the observation group were (43.84 ± 7.65)% ,(1.70 ± 0.18) and (37.78 ± 7.51)% ,respectively,which in the control group were (36.12 ± 6.57)% ,(1.52 ± 0.19) and (31.07 ± 4.20)% ,respectively,there were statistically significant differences between the two groups ( t =5. 413,4. 863, 6.124,all P<0.05).The objective response rate of the observation group (64% ) was significantly higher than that of the control group(44% )(χ2 =4.026,P<0.05).The incidence rate of adverse reaction of the observation group (18% ) was significantly lower than that of the control group(36% ) (χ2 =4.110,P<0.05).Conclusion Enteral nutritional emulsion can effectively improve the nutritional status and immune function of patients with gastrointestinal cancer during chemotherapy,but also can effectively enhance sensitivity to chemotherapy,improve the effect of chemo-therapy,and the safety is reliable.