摘要目的 研究特发性全身强直-阵挛发作(GTCS)患儿智商(IQ)及影响因素.方法 选择皖南区20个GTCS家系中所有28名年龄在9～16岁GTCS患儿作为癫痫组,与年龄、性别可比的同胞(对照组1)及同村健康儿童(对照组2)相比较,研究3组儿童的IQ及GTCS患儿智商的影响因素,所有数据用SPSS12.0进行分析.P＜0.05为有统计学意义.结果 ①癫痫组儿童的平均总智商[(85.64±20.57)分]比对照组1[(103.39±11.17)分]及对照组2[(106.17±11.67)分]低.除填图与图片排列外,癫痫组的所有其他分测验得分均低于两对照组,差异具有统计学意义(P＜0.01).②对照组1与对照组2之间的IQ及各分测验得分差异无统计学意义.③GTCS患儿IQ与父亲受教育程度(r=0.453,P＜0.01)、癫痫发病年龄( r=0.506,P＜0.01)、癫痫发作病程(即自第1次癫痫发作至最后1次发作的时间阶段,r=-0.533,P＜0.01)、癫痫发作频率(r=-0.708,P＜0.01)、癫痫持续状态(r=-0.732,P＜0.01)显著相关.结论 特发性GTCS患儿IQ明显低于同胞及一般健康儿童；影响GTCS患儿IQ的癫痫相关变量有癫痫发作病程、癫痫持续状态、癫痫发病年龄、总的癫痫发作次数、癫痫发作频率.

abstractsObjective To study the intelligence quotient(IQ) profile of the children with idiopathic generalized tonic-clonic seizure (GTCS) and the factors influencing IQ of them.Methods All 28 children with GTCS were selected who were aged 9 ～ 16 years in 20 GTCS families in a mountain area of the south of Anhui Province,all available healthy siblings of the children included in the epilepsy group,did not have epilepsy,and were nearest in age to the children with GTCS ( control group 1 ),and thirty children aged 9 ～ 16 years old who had lived in the same village ( control group 2) entered into our study.The IQ was studied of the three groups of children and the factors influencing IQ of children with GTCS at the same time.The data were input SPSS12.0 and analyzed.Results The IQ of children with GTCS(85.64 ±20.57)was lower than that control group 1( 103.39 ± 11.17)and the control group 2 ( 106.17 ± 11.67).The difference between children with GTCS and the two control groups were significant for almost all the subtest quotients except completion of drawing and picture arrangement.No significant differences were found between the control group 1 and the control group 2 on the IQ and the subtest quotients.IQ scores of children with GTCS showed significant linear correlation with father's education( r=0.453,P＜0.01 ),age at onset of epilepsy( r=0.506,P＜0.01 ),duration of seizure disorder( r=-0.533,P＜0.0l ),status epilepticus( r=-0.732,P＜0.01),total number of seizures( r=-0.761,P＜0.01) and seizure frequency ( r=-0.708,P ＜ 0.01 ).Conclusion The IQ scores of the children with idiopathic GTCS are lower significantly than general children population.Epilepsy-related variables affecting IQ scores of the children with idiopathic GTCS are duration of seizure disorder,status epilepticus,age at onset of epilepsy,total number of seizures,seizure frequency.