摘要目的 探讨抑郁症患者血清细胞因子水平及与性别、年龄、抑郁焦虑严重程度之间的相关性.方法 抑郁症组和对照者在入组后由经过培训的同一研究者完成入组对象的一般资料及HAMA、HAMD评分的采集及评定;采用ELSIA检测其血清白介素-1β(Interleukin-1β,IL-1β)、白介素-6(Interleukin-6,IL-6)及肿瘤坏死因子-α(Tumor necrosis factor-a,TNF-α)水平.结果 ①抑郁症组血清IL-1β、IL-6、TNF-α水平[分别为(5.45±3.60) pg/ml、(5.09±3.74) pg/ml、(5.77±3.94) pg/ml]明显高于对照组[分别为(2.63±1.92) pg/ml、(3.83±2.71) pg/ml、(4.05±3.25) pg/ml],均差异具有统计学意义(均P＜0.05);②男、女患者血清IL-1β、IL-6、TNF-α水平差异无统计学意义(均P＞0.05);③青、中年患者血清IL-1β、IL-6、TNF-α水平差异无统计学意义(均P ＞0.05);④重度抑郁症患者血清IL-6水平[(6.24±4.68) pg/ml]明显高于轻中度患者[(3.95± 1.97) pg/ml],差异有统计学意义(t=2.467,P＜0.05);⑤伴焦虑症状抑郁症患者血清IL-6水平[(5.80±4.37) pg/ml]高于不伴焦虑症状抑郁症患者[(3.87±1.80) pg/ml],差异有统计学意义(t=2.397,P＜0.05).结论 ①抑郁症患者普遍存在免疫功能激活、血清炎性细胞因子浓度升高的现象;②性别、年龄因素对抑郁症患者细胞因子的影响不显著;③IL-6水平可能是反映抑郁症患者抑郁、焦虑程度的生物学指标.

abstractsObjective To explore the serum levels of cytokines in patients with depression and their correlations with sex,age,depression severity and anxiety severity.Methods After enrolling subjects into the corresponding patient group and control group,the same trained researcher should continue to collect general information of the enrolled subjects as well as the HAMA and HAMD scoring results collection and assessment;And the serum levels of interlukin-1β (IL-1β),interlukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected with the method of enzyme-linked Immuno-sorbent assay (ELISA) in two groups.Results ① The serum levels of IL-1β,IL-6 and TNF-α of depression group were significantly higher than these in control group (P＜0.05),which were ((5.45±3.60) pg/ml vs(2.63± 1.92) pg/ml,(5.09±3.74) pg/ml vs (3.83±2.71) pg/ml,(5.77±3.94) pg/ml vs (4.05±3.25) pg/ml) respectively.②There was no significant difference in serum levels of IL-1 β,IL-6 and TNF-α between male and female patients with depression (P＞0.05).③ No conspicuous differences were found between the young group and the middle-aged group in serum levels of IL-1β,IL-6,TNF-α (P＞0.05).④ Serum level of IL-6 in major depressive disorder group((6.24±4.68) pg/ml) was more higher than that in mild to moderate depression group((3.95± 1.97)pg/ml),and the difference was statistically significant (t=2.467,P＜0.05).⑤There was significant differences in serum level of IL-6 between two groups,which were depression patients with and without anxiety (separately(5.80±4.37) pg/ml vs(3.87±1.80) pg/ml) (t=2.397,P＜0.05).Conclusions ①There is a phenomenon of immune activation,and levels of blood cytokines are raised in patients with depression.②Age and gender have no impact on depression in the level of cytokines.③IL-6 may be an important biological index that reflected the severity of depression and anxiety.