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Experimental study on new self and mutual-aiding occlusive dressing for wound

摘要:

Background Self and mutual-aiding occlusive dressing is a novel method to treat with the wounds in special circumstances.This study aims to prepare a new antimicrobial adhesive for the dressing and evaluate the application effects of the adhesive.Methods The main component of the new antimicrobial adhesive was 5% triclosan / cyanoacrylate (CA) antimicrobial adhesive.The adhesive was modified with carboxylic multi-walled carbon nanotubes (MWCNTs-COOH),multi-walled carbon nanotubes (MWCNTs),hydrophobic nano-silica,nitrile rubber,epoxy resin and polymethyl methacrylate (PMMA) respectively.The bond strength,toughness and viscosity of the modified adhesive in different concentrations were examined to select the optimal modifying material and the best ratio to prepare the new antimicrobial adhesive according to the results.After that,the antimicrobial property of the new antimicrobial adhesive was tested by filter paper method.At last,we disposed the injury models in rats using the new antimicrobial adhesive to examine the application effects.Results In individual tests,the bond strength modification performance of 0.064% MWCNTS-COOH is the best,the bond strength is (14.71±1.48) Mpa.8% nano-silica shows the best toughness modification performance,the Tg is (1.10±0.24)℃.The viscosity modification performance of 8% nano-silica is the best,the viscosity is (15 536.68±28.4) cP.However,consolidating three test results,6% nano-silica / antimicrobial adhesive has the balanced bond strength,toughness and viscosity.Its bond strength is (14.03±1.92) Mpa,the Tg is (3.60±0.68)℃,and the viscosity is (5 278.87±31.68) cP.The inhibition zone diameter of 6% nano-silica / antimicrobial adhesive and antimicrobial adhesive group in Day 5 is (28.61±0.91) mm versus (28.24±2.69) mm (P >0.05).In animal studies,both in blood routine test and pathological section,6% nano-silica / antimicrobial adhesive group shows lower white blood cells count than gauze bandage group (P <0.05).Conclusions 6% nano-silica has the optimal effect of bond strength modification,toughness modification and viscosity modification,and the antimicrobial adhesive modified with it has a good antimicrobial property (resistant staphylococcus aureus).

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作者单位: Orthopedics Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China [1] Orthopedics Department, No.252 Hospital of People's Liberation Army, Baoding, Hebei 071000, China [2]
期刊: 《中华医学杂志(英文版)》2014年127卷7期 1321-1327页 SCIMEDLINEISTICCSCDBP
栏目名称: ORIGINAL ARTICLES
DOI: 10.3760/cma.j.issn.0366-6999.20132752
发布时间: 2014-04-25
基金项目:
This study was supported by a grant from the S&T Research Program of People's Liberation Army General Logistics and the International S&T Cooperation Program of China
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