摘要目的 探讨氨糖软骨素钙片对膝关节骨关节炎的辅助治疗作用,并观察服用过程中有无不良反应及其耐受情况. 方法 回顾性分析2013年3月至2014年2月期间收治且获得随访的103例膝关节骨关节炎患者资料.根据是否服用氨糖软骨素钙片分为两组:试验组53例,男23例,女30例;年龄为(71.0±9.1)岁;服用氨糖软骨素钙片,2片/次,2次/d,同时配合进行功能康复锻炼,24周.对照组50例,男22例,女28例;年龄为(69.8±8.8)岁;服用安慰剂,2片/次,2次/d,同时配合进行功能康复锻炼24周.所有患者服用氨糖软骨素钙片或安慰剂期间不能同时服用非甾体类抗炎药、含钙或其他软骨保健类产品. 结果 治疗后试验组患者的膝关节活动度(123.27°±10.22°)显著大于对照组患者(116.34°±8.76°),走40 m疼痛视觉模拟评分[(2.92±0.36)分]显著低于对照组患者[(3.30±0.22)分],差异均有统计学意义(P＜0.05);而两组患者的西安大略和麦克马斯特大学关节炎评分、走40m的时间及膝关节周径的比较差异均无统计学意义(P＞0.05).随访期间两组患者均未发生并发症. 结论 膝关节骨关节炎患者服用氨糖软骨素钙片配合功能锻炼,可以明显缓解疼痛及改善功能,且随访期间不会发生并发症.

abstractsObjective To study the effectiveness,side effects and safety of glucosamine chondroitin sulfate calcium (Keylid(R)) tablets for osteoarthritis of the knee.Methods To review the clinical data of 103 cases of primary knee osteoarthritis who had been treated between March 2013 and February 2014.The intervention group included 53 cases (23 males and 30 females with an age of 71.0 ± 9.1 years) who received Keylid(R) tablets (2 tablets twice per day) accompanied with exercise therapy for 24 weeks;the control group included 50 cases (22 males and 28 females with an age of 69.8 ± 8.8 years) who received placebo (2 tablets twice per day) accompanied with exercise therapy for 24 weeks.No NSAIDs,calcium or other articular dietary supplements were taken by the 2 groups during the study period.T-test was used to analyse the results.Results After treatment,the range of knee motion for the intervention group (123.27° ± 10.22°) was significantly larger than that for the control group (116.34° ± 8.76°),and the average pain visual analogue score after 40 m walking for the former (2.92 ± 0.36) significantly lower than that for the latter (3.30 ± 0.22) (P ＜ 0.05).There were no significant differences between the 2 groups in Western Ontario and McMaster Universities Arthritis Index,time for 40 m walking or circumference of the knee (P ＞ 0.05).No side effects were observed in either group during the study period.Conclusion Keylid(R) tablets complemented with exercise therapy may reduce pain and improve knee function with no adverse events in the patients with knee osteoarthritis.