妊娠期妇女人细小病毒B19感染与死胎及胎儿畸形关系的研究
The Relationship between maternal infection with human parvovirus B19 and fetal death and congenital malformation
目的 了解妊娠期妇女人细小病毒B19(human parvovirus B19,简称B19)感染与死胎及胎儿畸形的关系。方法 采用前瞻性的研究方法,应用聚合酶链反应(PCR)技术对335例孕妇血清进行B19 DNA检测,并随访其妊娠结局。结果 在335例孕妇中,血清B19 DNA阳性67例,B19 DNA阴性268例。其中在67例B19 DNA阳性者中,发生4例死胎和1例无脑儿,在268例B19 DNA阴性者中,无一例发生死胎和胎儿畸形,阳性与阴性者间比较,差异有显著性(P<0.05)。两者正常分娩的新生儿外观均无异常。结论 妊娠期妇女感染B19可导致死胎和胎儿畸形发生。
更多Objective To study the relationship between matanal infection with human parvovirus B19 and fetal death and congenital malformation. Methed B19-DNA was detected by Polymerase Chain Reaction (PCR) in blood samples from 335 pregnant women. The pregnant outcomes were followed. Results In 335 pregnant women, 67 cases were B19-DNA positive and 268 cases were B19-DNA regative. There were four fetal deaths and one anencephalus in B19-DNA positive group. There was no fetal deaths or congenital malformation in B19-DNA negative group. The difference is significant (P<0.05). Conclusions Maternal infection with human parvovirus B19 may contribute to fetal death and congenital malformation.
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