摘要目的 探讨良性前列腺增生(BPH)患者围手术期膀胱痉挛的有效防治方法.方法 BPH患者112例,随机分为2组,每组56例.治疗组应用酒石酸托特罗定治疗,术前4～5 d,术后3～4 d,2 mg,2次/d.对照组不服用任何对膀胱痉挛有影响的药物.观察比较2组患者经尿道前列腺切除术后膀胱痉挛发生频率、持续时间等.结果 对照组56例患者麻醉效应过后未发生膀胱痉挛7例(12.5%)、轻度膀胱痉挛(偶感耻骨上膀胱区及尿道疼痛不适)8例(14.3%)、膀胱痉挛(膀胱区阵发性疼痛伴尿液自尿管周围溢出)41例(73.2%).治疗组56例患者麻醉效应过后未发生膀胱痉挛49例(87.5%)、轻度膀胱痉挛5例(8.9%)、膀胱痉挛2例(3.6%).2组膀胱痉挛发生率比较差异有统计学意义(P<O.001).2组患者均无严重不良反应发生,拔除尿管后排尿均通畅.结论 BPH围手术期应用托特罗定防治膀胱痉挛,可减轻患者痛苦、防止出血和尿管堵塞,临床效果满意、安全.

abstractsObjective To evaluate the efficacy of tolterodine in preventing bladder spasm during the operation to BPH.Methods One hundred and twelve cases of BPH patients were randomized to two groups:56 cases in one group were prescribed tolterodine 4-5 d before operation and 3-4 d after operation (2 mg twice daily),another 56 cases did not take any anti-spasm drugs.The bladder spasm occurring or not,frequency and continuing time of bladder were evaluated and recorded.Results In the controlling group:the non bladder spasm in 12.5% (7/56),mild bladder spasm in 14.3% (8/56),severe bladder spasm in 73.3% (41/56),In the treatment group:non bladder spasm in 87.5% (49/ 56),mild bladder spasm in 8.9% (5/56),severe bladder spasm in 3.6% (2/56).There was signifi-cant difference between the 2 groups (P<0.001).Conclusion Tolterodine could alleviate bladder spasm around the operation to BPH.