摘要免疫球蛋白G(IgG)是血清中免疫球蛋白的主要成分,IgG抗体又分为IgG1、IgG2、IgG3和IgG4 4个亚类,IgG亚型的缺陷或比例失调是引起免疫反应的1项指征,4个不同的亚类抗体在疾病发生发展过程中发挥不同的作用.近年来,随着人们对lgG抗体及亚类认识的逐步深入,尤其是对IgG4相关性疾病的定义及研究,使IgG亚类在相关疾病中的临床意义逐步得到国际社会的关注和重视.

abstractsThe immunoglobulin G (IgG),a major effective molecule of the humoral immune response in man,comprising four different subclasses IgG1,IgG2,IgG3 and IgG4.Deficiency and imbalance of IgG subclasses are an indication of a disturbed immune response.The four IgG subclasses play a different role in the development of diseases.As well understanding of IgG and IgG subclasses in recent years,especially after the definition and study of IgG4 related disease,the clinical significance of IgG subclasses are getting the international concern and attention.